Before I start on the matchups, I wanted to address a question that reader Scott Berger asked: "What is the current thinking on Bedard?". I'm glad he asked, because this raises a few interesting points. When I'm down on a talented pitcher coming back from injury, it doesn't take much for me to change my mind. Bedard's eight strikeout, no walk performance definitely impacts my opinion of his effectiveness. I'm not saying I expect him to be dominant like in 2007, but this definitely makes it substantially more likely that he's healthy enough to pitch effectively. Strikeout rate in particular is a VERY sensitive indicator with great predictive ability. If he has two or three more games like that, I'd be sure he's fine. As it is, he's worth getting if cheap in any format, and I'd now consider him in certain situations in daily contests.
For today's matchups, Lincecum is the clear standout on the pitching side. He's already possibly the best pitcher, and he'll be in the best pitcher's park in baseball against a weak offense. Interestingly, his opponent Chris Young is probably one of the best bargains among those looking for a less expensive pitcher in daily contests.
On the hitting side, the White Sox, Rays, Mariners, Phillies, and Rockies are in favorable situations. Unfortunately, there appears to be a threat of rain for the Phillies-Rockies game, so they should be avoided if possible. There's also a threat of rain for the Yankees-Royals game.
The White Sox are at home in a hitters park against a relatively weak pitcher. While Blackburn has good enough control to keep his ERA in check, his low strikeout rate makes his a good target for opposing hitters...especially those prone to strikeout a lot against better pitchers. Sometimes these things aren't symetrical. A wilder pitcher with a better strikeout rate might be a worse choice to have on your team than Blackburn, but also a tougher matchup for opposing hitters.
The Rays and Mariners both face bad pitchers, although they're both on the road and in the Mariners' case in a tough ballpark, so their hitters may not present as good an opportunity.